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4 Most Profitable Small-Business Industries in 2018 Offices of Physicians: 13.01% Offices of Physicians: 13.01% Image credit: Shutterstock Being a doctor requires years of training, certification and likely, medical school debt. However, doctors also benefit from regular clients and relatively low overhead costs. Commercial and Industrial Machinery and Equipment Rental and Leasing: 12.58% Commercial and Industrial Machinery and Equipment Rental and Leasing: 12.58% Image credit: Shutterstock It pays to rent or lease. These businesses typically rent or lease commercial machinery and equipment across industries. Religious Organizations: 12.41% Religious Organizations: 12.41% Image credit: Shutterstock Religious organizations are having a profitable year. Really. Remember, being not-for-profit doesn't mean your goal shouldn't be to make a profit. It's just how you distribute those gains. Instead of giving profits to shareholders, all of yours go to your organization's mission, which is the furthering of your church's aims. It has been a good year not only for churches, synagogues, monasteries, mosques and temples, but also for schools, colleges and universities that are operated by religious organizations. Management, Scientific and Technical Consulting Services: 12.05% Management, Scientific and Technical Consulting Services: 12.05% Image credit: Shutterstock Some types of businesses that fall under this category are businesses that provide either management or consulting on a range of expertise, including human resources, marketing and environmental issues. Specialized Design Services: 11.4% Specialized Design Services: 11.4% Small businesses that specialize in interior, industrial and graphic design are flourishing, as the value of a product or business’s function has become inextricably linked to appearance and design.