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Sarcomatoid cell types are mainly found in pleural mesothelioma patients. It is the rarest form of mesothelioma and least treatable. What is Sarcomatoid Mesothelioma? Sarcomatoid cells metastasize faster than other mesothelioma cell types, causing the formation of cancerous tumors in other areas of the body. This makes sarcomatoid the most dangerous cell type, though new treatments are leading to longer life expectancies. Sarcomatoid mesothelioma only accounts for about 10-15 percent of all mesothelioma diagnoses. Characteristics of Sarcomatoid Cells Cell Description The cells are spindle-shaped and have an enlarged, elongated nucleus. These cells sometimes have multiple nuclei and are harder to distinguish from healthy tissue. Cell Behavior Sarcomatoid cells do not bundle themselves in a uniform way like epithelioid cells. This contributes to the cells’ ability to spread faster than other cell types. Guide Book Covers OUR FREE MESOTHELIOMA GUIDE INCLUDES: 200+ Pages about your diagnosis 3 Books to improve your prognosis Wristbands to show your support SENT OVERNIGHT! Get your free guide Diagnosis Sarcomatoid Mesothelioma Cell TypeSarcomatoid cell types are found in 10-20 percent of pleural mesothelioma and in 4 percent of peritoneal mesothelioma diagnoses. They are also found in bladder, kidney, lung, and liver cancers. The diagnosis of sarcomatoid mesothelioma is difficult because of the similarity to benign tissue cells. Sarcomatoid mesothelioma is commonly misdiagnosed as fibrous pleurisy, fibrosarcoma, and metastasized renal cell carcinoma. Knowing the symptoms of the disease can prepare patients for what to expect. Symptoms get more intense as tumors begin to spread. Below are some general symptoms of sarcomatoid mesothelioma. Symptoms of sarcomatoid mesothelioma of the pleura include: Weight loss Fatigue Shortness of breath Difficulty breathing Symptoms of sarcomatoid mesothelioma of the peritoneum include: Loss of appetite Nausea Pain of the abdomen Swelling Since sarcomatoid cells are so hard to differentiate from other cell types, doctors use a process called immunohistochemistry. This process is a tissue staining technique that makes proteins in the cell samples more visible under a microscope. Subtypes of Sarcomatoid Mesothelioma Transitional Mesothelioma Behaves like standard sarcomatoid cell types Plump, spindle-shaped Lymphohistiocytoid Mesothelioma Contain a large amount of inflammatory and immune cells (1% of all diagnoses) Large, spindle-shaped Desmoplastic Mesothelioma Difficult to diagnose, patternless (5% of all diagnoses) Long and collagen bundles READ SURVIVOR STORIES Photograph of J Page Jodi Page Pleural Mesothelioma survivor for 17 years. Photograph of P Kraus Paul Kraus Peritoneal Mesothelioma survivor for 20 years. Photograph of a woman Alexis Kidd Peritoneal Mesothelioma survivor for 9 years. Get a Free Survivors Guide Treatment Treatment for sarcomatoid cell types is difficult because it is the most aggressive cell type of mesothelioma. Although surgery, chemotherapy, and radiation are the treatment options most used with sarcomatoid mesothelioma, surgery can be difficult. Sarcomatoid mesothelioma is very rigid when it attaches to the chest wall and it is difficult to remove. In peritoneal mesothelioma instances, the tumor cases around the intestines which also makes it harder to remove. Although chemotherapy does not show as much success in shrinking tumors, there have been new discoveries made. Researchers have discovered that a drug called doxorubicin works effectively on its own and when combined with other chemotherapy drugs. Sarcomatoid mesothelioma is difficult to treat, but with new advances, researchers hope to see survival rates increase over the next few years. Get connected with a mesothelioma specialist who can help improve your survival rate. Ask a Nurse Prognosis The prognosis for sarcomatoid cell mesothelioma is not as positive as other cell types. The median survival rate for patients is around six months. However, there have been patients that have survived up to six years past their initial diagnosis date. Patients with lymphohistiocyoid mesothelioma have the best prognosis. A patient’s prognosis is largely dependent upon available treatment options and the cancer’s stage at discovery. Every prognosis, no matter how dire, has had cases of survival. There have been survivors living with mesothelioma for 5+ years after a sarcomatoid mesothelioma diagnosis.
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